Genetic screens provide global information about how genes are regulated in normal conditions and how they are deregulated during disease. In addition to providing insights into gene function these approaches identify targets for drug development.

 

Recent technological advances include CRISPR based technologies as well as advances in screening technologies are revolutionising our ability to use functional genomics. Research in the Rosenbluh lab uses state of the art functional genomic tools that including pooled CRISPR  loss/gain of function screens and apply these technologies towards identifying genes  associated with cancer and developing new approaches to treat cancer.